https://www.sciencedaily.com/releases/2024/05/240501125227.htm
This could be helpful for research into physically-induced PEM.
"They found that each of the organs they looked at changed with exercise, helping the body to regulate the immune system, respond to stress, and control pathways connected to inflammatory liver disease, heart disease, and tissue injury."
"In all, the teams performed nearly 10,000 assays to make about 15 million measurements on blood and 18 solid tissues. They found that exercise impacted thousands of molecules, with the most extreme changes in the adrenal gland, which produces hormones that regulate many important processes such as immunity, metabolism, and blood pressure. The researchers uncovered sex differences in several organs, particularly related to the immune response over time. Most immune-signaling molecules unique to females showed changes in levels between one and two weeks of training, whereas those in males showed differences between four and eight weeks."
I previously thought of induction of PEM from exertion as fairly simple: damage to muscle cells triggers an immune response, and 24 hrs later, IFN-g triggers glial response, resulting in symptoms. This study offers way more possible pathways. The data might correlate with PEM responses, although ME varies so much that it might be hard to spot a correlation. Still, such large-scale data might reveal something, or trigger some new hypotheses for ME.
Their study seems focused on long-term changes from long-term (from PWME's perspective) exercise, but it should show some short-term pathways from mild activity too.
This could be helpful for research into physically-induced PEM.
"They found that each of the organs they looked at changed with exercise, helping the body to regulate the immune system, respond to stress, and control pathways connected to inflammatory liver disease, heart disease, and tissue injury."
"In all, the teams performed nearly 10,000 assays to make about 15 million measurements on blood and 18 solid tissues. They found that exercise impacted thousands of molecules, with the most extreme changes in the adrenal gland, which produces hormones that regulate many important processes such as immunity, metabolism, and blood pressure. The researchers uncovered sex differences in several organs, particularly related to the immune response over time. Most immune-signaling molecules unique to females showed changes in levels between one and two weeks of training, whereas those in males showed differences between four and eight weeks."
I previously thought of induction of PEM from exertion as fairly simple: damage to muscle cells triggers an immune response, and 24 hrs later, IFN-g triggers glial response, resulting in symptoms. This study offers way more possible pathways. The data might correlate with PEM responses, although ME varies so much that it might be hard to spot a correlation. Still, such large-scale data might reveal something, or trigger some new hypotheses for ME.
Their study seems focused on long-term changes from long-term (from PWME's perspective) exercise, but it should show some short-term pathways from mild activity too.
