Violeta
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SARS-CoV-2 and EBV; the cost of a second mitochondrial “whammy”?
https://immunityageing.biomedcentral.com/articles/10.1186/s12979-021-00252-xOctober, 2021
"The association between EBV-induced chronic fatigue syndrome with mitochondrial dysfunction was suggested many years ago [15]. EBV can alter mitochondrial dynamics and DNA replication [20, 21], as well as interact with latent membrane protein 1 (LMP1) and dynamin-related protein 1 (Drp1), enhancing glycolysis [22]. "
We, and others, have suggested that as the SARS-CoV-2 virus may modulate mitochondrial function, good mitochondrial reserve and health could be key in determining disease severity when exposed to this virus, as the immune system itself is dependent on this organelle’s function.
With the recent publication of a paper showing that long COVID could be associated with the reactivation of the Epstein Barr Virus, which is well known to manipulate mitochondria, we suggest that this could represent a second mitochondrial “whammy” that might support the mitochondrial hypothesis underlying COVID-19 severity and potentially, the occurrence of longer-term symptoms.
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