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This is the second time that I've experienced a reaction to local anaesthetic that was administered by my dentist.
I become drowsy during procedure and afterwards (yesterday) I developed light headedness, severe nausea (still lingering), shakes and tremors. Vision blurred.
The nurse gave me dextrose tablet and on gums. I was tipped back on a bed with a fan on me, I wasn't cold.
After a while I felt that I could sit up (I desperately wanted to go home, I was feeling very ill and didn't want to end up in hospital, I avoid that at all costs) I was still weak and dizzy.
I relapse afterwards and feel very ill.
Has anyone else experienced this kind of reaction to local anaesthetic?
Local anaesthetics containing adrenaline need to be used with caution in people who have autonomic nervous system dysfunction - as can occur in ME/CFS
I had it done in hospital as I was 'foolish' enough to tell my dentist I am not well after injections - he took it to mean I would be ill in the chair - but for me its days afterwards.Sorry @welshbabe that you are still having problems with dental anaesthesia. Sounds quite dramatic to have to have treatment in hospital.
Good luck with your next treatment.
I had a dental procedure today with local anesthetic, what I assumed was Lidocaine. Almost immediately I had intense tremors in my arms and right leg and felt a surge of terror which made no sense, my blood pressure shot up from 110/68 to 148/100.
I am so sorry this happened to you! Do you know if the lidocaine contained Epinephrine (Adrenaline)?
For people w/a history of MCAS & POTS (like myself), I am supposed to use Mepivocaine without Epi (and without dyes) for dental work.
"...avoid the use of anaesthetic solutions containing adrenaline if you suffer from ME."
Just updating the chain, my dentist confirmed she used Lidocaine + Epinephrine. The Epi is likely what caused reaction. She added a note to my chart to not use Epi again.
The chronic lack of activation of the sympathetic nerve cell would lead to up-regulation of the post-synaptic adrenergic receptors on the muscle cell controlling the blood vessel, leading to a more sensitive neuromuscular connection.
He backs up this idea with two experimental observations:
- If you inject a POTS patient with norepinephrine, they exhibit excessive vasoconstriction, with profound circulatory effects. This is also seen in ME patients when they go to the dentist and are injected with a local anesthetic that contains epinephrine - the ME patients exhibit profound, scary circulatory symptoms. (which is why ME patients are advised to specifically ask for a non-epinephrine anesthetic when they visit the dentist)
- If you stimulate the sympathetic nervous system in POTS patients, only a low level of norepinephrine is released, suggesting that the sympathetic nerve cells are not releasing their neurotransmitters appropriately.
From: Insights from Invasive Cardiopulmonary Exercise Testing of Patients with ME/CFS (Joseph et al., 2021)
https://forums.phoenixrising.me/thr...patients-with-me-cfs-joseph-et-al-2021.82907/
Immunohistochemical studies show that small fibers regulate microvascular tone, primarily by sympathetic and parasympathetic cholinergic synapses on perivascular myocytes. [...] Abnormal venous pooling in the legs on standing is demonstrated in POTS, and the excess peripheral venoconstriction to experimentally infused norepinephrine or phenylephrine documented is consistent with classic post-denervation adrenergic receptor upregulation. This is further supported by low norepinephrine release after sympathetic nervous system stimulation in POTS patients.
I remember when I was about aged ten I was having an extraction after the injection. I hadn't gone numb and as the tooth was being pulled my mum heard me yell out while she was in the waiting room.!!!Wow, I have to remember this! I don't numb, and I have hypermobility/EDS...
My mom has made sure since I was a little kid that the anesthetist knew there was a family allergy, so I have always had "safe" anesthetics. But locals don't numb me!