Dreambirdie
work in progress
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Has anyone here tried the liposomal glutathione? I am wondering if it would be as helpful as the Lee Silsby's transdermal glutathione...?
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I usually take 2 600 mg tablets (the Jarrow sustain) for mild toxicity, but have taken as much 3600 mg/day during times when I have a major heavy metal clearing going on. I find it can be a little harsh on my stomach, but it works well to help my liver clear toxins. IN fact sometimes it has been the only thing that has helped me.
But, in the meantime, is there a dosage that you guys use while on the b12 protocol? (If you are using NAC; I realize it's not a required supp but I think it might help in my case since my cysteine is on the lower end.)
Thanks Dreambirdie. Those dosages are in line with what I was seeing in clinical trials (all of which had a very favorable outcome for NAC use ranging from detoxification to neurotoxicity protection to mental health issues). I know I have some mercury built up from a lack of glutathione being able to shepherd it out. Fortunately (if there is a fortunate side to mercury build up!), it's from eating fish in my case, so at least I can easily control the source.
So your only side effects from the NAC have been stomach problems?
Hi, lolasana.
Yes, if the amino acids are too low, the cells will not be able to make glutathione. Normally, the rate-limiting amino acid for making glutathione is cysteine, but if one of others gets too low, it will become rate-limiting.
Amino acids are often found to be low in PWMEs. This can be caused by a low-protein diet, by poor digestion of proteins and absorption of amino acids by the gut, or by excessive burning of amino acids for fuel, because the burning of carbs and fats is limited in ME/CFS by a partial block early in the Krebs cycle at aconitase. Also, I think because of the last-mentioned issue, many PWMEs go low in B6 (or its active form P5P) because of heavy use by the transamination reactions. These are needed to convert one amino acid into another to feed them into the Krebs cycle, so when it goes low, there will be high and low levels of various amino acids, and it becomes difficult to feed them into the Krebs cycle for fuel. This then makes the person more fatigued.
There are free form amino acids supplements, and supplementing B-complex vitamins can also help, if they are low.
Best regards,
Rich