ChookityPop
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Is there a way to correct collagen issues?Do we know if CCI is treatable or reversible if the collagen issues are corrected?
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Is there a way to correct collagen issues?Do we know if CCI is treatable or reversible if the collagen issues are corrected?
Is there a way to correct collagen issues?
I don't think the doxy helped much, at least based on using receding gums as a measurement. IIRC I took it for at least 2 months, but probably three. No gut changes at such a low dose.What are you eating now? And how did the low dose doxy go? Very interesting. How is that for the gut flora though?
I have issues with B12, folate and some type of collagen problem.
Consider getting your urine methylmalonic acid level tested (it's a B12 test). If your doctor won't order it, you can order it yourself using one of those online labs. I cannot express how important this is for some of you.
@HipLooks like aloe vera as well as neem are MMP-2 and MMP-9 inhibitors:
This in vitro study found :
aloe vera inhibited:
MMP-2 by 20%
MMP-9 by 20%
neem inhibited:
MMP-2 by 54%
MMP-9 by 53%
doxycycline inhibited:
MMP-2 by 82%
MMP-9 by 83%
And another in vitro study found:
doxycycline inhibited:
MMP-9 by 59%
triphala inhibited:
MMP-9 by 77%
I will add these to the original post.
How about minocycline?
So do u know if the other tetracycline like minocycline help too? I know minocycline is otc in mexico and I am wanting to take a Mexico trip. I wonder if doxy is otc there ...Well the tetracycline class of antibiotics are good broad-spectrum MMP inhibitors, with doxycycline being one of the most potent inhibitors (doxycycline is also a reasonably safe antibiotic). Doxycycline inhibits MMP-1, 2, 7, 8, 9, 12 and
So do u know if the other tetracycline like minocycline help too? I know minocycline is otc in mexico and I am wanting to take a Mexico trip. I wonder if doxy is otc there ...
Minocycline showed the highest potency in MMP-9 inhibition (P < 0.0001), while tetracycline was found to be more potent than doxycycline in MMP-9 inhibition
Whoa. Okay. Good stuff. But mmps9 is not the most important , correct?This paper says minocycline is actually strong than doxycycline for MMP-9 inhibition:
Okay. Good stuff. But mmps9 is not the most important , correct?
Hi Frozenborderline,Took first dose
My trial isnt likely to be conclusive as I'm just trying to prevent further damage. And I haven't had upright imaging to check for damage lower down relative to my first scan. It's just sort of a prophylactic , I don't expect it to actually reverse any damage, and I can't get out to the lab often enough to track mmp-9 regularlyHi Frozenborderline,
I appreciate it's early days for your regarding Doxycycline, but can you please keep me in the loop with how you progress and whether it has any effect? I have developed ME-like symptoms from what I believe is an acquired connective tissue disorder courtesy of damage to my collagen and elastin caused by Minoxidil - it's an odd situation, I appreciate. Anyway, since connective tissue degradation is a feature of my disease, I think there's a good chance that Doxycycline could help me, but I'm having trouble obtaining it. It would be really handy to hear some stories from people who have benefited to help me get a prescription from my doctor.
All best,
Flex
There are many ways to obtain doxycycline without a doctors help, so I wouldn't wait until you hear some good stories on a forum and count on that to help get the script. There are actual studies , you know. On it helping with connective tissue problems and regeneration along with prp. But you could just use one of the pharmacies @Hip recommends. Or maybe even get the fish version on amazonI'm having trouble obtaining it. It would be really handy to hear some stories from people who have benefited to help me get a prescription from my doctor.
I just want to add that using doxy for CCI is wildly irresponsible IMO. Antibiotics do so much damage to our microbiomes and immune systems and given that ME/CFS patients already have a lot of issues there, it’s like adding water to one fire and gas on another in the same room
The low dose of doxycycline taken for anti-MMP effects is below the dose level that has antibacterial effects, and this low dose been shown in studies to have no effect on the microbiome composition after 9 months (see study in the first post).
But certainly long term heavy use of antibiotics has sometimes made ME/CFS patients permanently worse (although has helped others).