Hello,
My doctor is proposing Rituximab treatment for autoimmunity. However, I don't feel my lab data is very compelling for autoimmunity.
ANA titer:
Positive 2 of 8 times with positive value of 1:40 (Ref Range < 1:40)
Mayo Dysautonomia Autoimmune Panel (3 times)
a. N-Type Calcium Channel Ab (VGCC): 0.10
(7/11/2018), 0.51 (3/30/2019), 0.22 (5/3/2020) (Ref Range < 0.03)
b. Neuronal K+ Channel Ab (VGKC) 0.07
(7/11/2018), 0.03 (3/30/2019), 0.03 (5/3/2020) (Ref Range < 0.02)
All other autoimmunity panels negative.
What do you think?
Background info:
I have been suffering with health issues since 2014. Diagnosis currently include POTS confirmed twice via TTT, vestibular migraines, central vestibular issues confirmed via VNG, intractable headaches, and ME/CFS.
I'm seeing some improvement with Clonidine transdermal patch for POTS and Cyproheptadine for headaches and Vestibular therapy for central vestibular issues.
Prior to the three above treatments, I was bed bound 23 hours per day, and now I'm bed bound/couch bound approximately 16-18 hours per day and house bound the remainder of the day.
My common component seems to be the brain stem which includes the vestibular nuclei (my vestibular issues) and autonomic nervous system (POTS).
My doctor is proposing Rituximab treatment for autoimmunity. However, I don't feel my lab data is very compelling for autoimmunity.
ANA titer:
Positive 2 of 8 times with positive value of 1:40 (Ref Range < 1:40)
Mayo Dysautonomia Autoimmune Panel (3 times)
a. N-Type Calcium Channel Ab (VGCC): 0.10
(7/11/2018), 0.51 (3/30/2019), 0.22 (5/3/2020) (Ref Range < 0.03)
b. Neuronal K+ Channel Ab (VGKC) 0.07
(7/11/2018), 0.03 (3/30/2019), 0.03 (5/3/2020) (Ref Range < 0.02)
All other autoimmunity panels negative.
What do you think?
Background info:
I have been suffering with health issues since 2014. Diagnosis currently include POTS confirmed twice via TTT, vestibular migraines, central vestibular issues confirmed via VNG, intractable headaches, and ME/CFS.
I'm seeing some improvement with Clonidine transdermal patch for POTS and Cyproheptadine for headaches and Vestibular therapy for central vestibular issues.
Prior to the three above treatments, I was bed bound 23 hours per day, and now I'm bed bound/couch bound approximately 16-18 hours per day and house bound the remainder of the day.
My common component seems to be the brain stem which includes the vestibular nuclei (my vestibular issues) and autonomic nervous system (POTS).