Welcome to Phoenix Rising!
Created in 2008, Phoenix Rising is the largest and oldest forum dedicated to furthering the understanding of, and finding treatments for, complex chronic illnesses such as chronic fatigue syndrome (ME/CFS), fibromyalgia, long COVID, postural orthostatic tachycardia syndrome (POTS), mast cell activation syndrome (MCAS), and allied diseases.
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In my experience, the best way to determine the need for antihistamines is to undergo a blood test for CD4 and CD8 cells. CD8 cells, while being implicated in allergic reactions, also continuously attack other cells, including red blood cells (RBCs).
I took 400mg cimetidine one time and it worsened my peripheral neuropathy substantially. Cimetidine can deactivate T-regulatory cells and worsen autoimmunity.