ME/CFS for 18 years, recently diagnosed with D-Lactic acidosis as cause of symptoms and illness.

[Wayne]

Any ideas for moving forward would be appreciated.

Hi @triceratops -- I think the following video is excellent, and may be something for you to consider. He focuses on constipation, but covers GI tract anatomy that is very useful for any type of GI issue. -- Best!

How I Reversed Chronic Constipation Using Coffee Enemas! | SIBO IBS-C Gallstones

 

[Aidan Walsh]

Franconi Syndrome can also come with Crystals forming in the eyes seen by eye specialists who use eye drops & medicines. Kidney transplants later are required & check always potassium levels

 

[Aidan Walsh]

I did see an autopsy report a Guy with mesentera compression in abdomen & his aorta vein undiagnosed, he also had the condition Fabry Disease diagnosed a genetic illness there are child onset or adult onset it runs in families

 

[Violeta]

The phenotype of fatigue exhibited by CFS/ME patients closely mirrors that seen in fatigue associated primary biliary cirrhosis patients (PBC). For example, Hollingsworth et al. [81] reported PBC patients to exhibit significant acidosis due to an overutilisation of the lactate dehydrogenase pathway, following a low-level repeat exercise protocol [81]. Furthermore, the authors postulated that the increased dependence on anaerobic pathways of energy production resulted in the fatigue associated with PDC. The idea that impaired PDC function leads to an overutilisation of the lactate dehydrogenase pathway is in agreement with other studies. For example, Murrough et al. [95] reported significantly higher levels of lactate in ventricular cerebrospinal fluid in CFS/ME patients when compared to healthy controls. Similarly, Constantin-Teodosiu and colleagues [96] in an experimental exercise model using rats demonstrated that when PDC function was decreased via the use of PPAR modulating drugs which upregulated PDK function, lactate accumulated intramuscularly which led to decreased muscle function.

https://www.hindawi.com/journals/jar/2016/2497348/

 

[Aidan Walsh]

Dr. Ron Davis in the OMF's last email said he found BH4 Deficiency in ME/CFS as the likely culprit it has also to do with carbs, Meat protein & one of the treatments is Folinic Acid 10-20mgs daily with other supplements there is no Cure but teatments are used with strict diets. This was from his seminare back in December 2023. He also said from other lab tests as many as 50% of ME/CFS patients have MS with ME/CFS x x