Consider these four patterns. person 1 - 40,000mgs/day absorbed mb12/adb12, 15000mcg Metafolin, 2000-3000mg potassium person 2 - 2000mcgs/day absorbed mb12/ADB12, 800mcg Metafolin, 99mg potassium person 3 - 50mcg/day absorbed mb12/adb12, 1600mcg Metafolin, 2100mg potassium person 4 - 200mcg/day absorbed mb12, 3200mcg Metafolin, 2400+mg potassium All four of these people titrated to effective dose when there was any indication of need. These titrations are not complete yet for persons 3 and 4 but are currently stable and this is the balance. Person 1 - huge body mb12 response, huge CNS mb12 response, Huge body response to adb12/l-carnitine-fumarate, CFS FMS, paradoxical folate deficiency. Large healing startup response including low potassium and low folate Person 2 - small CNS response to adb12, no blocked methylation, only a few symptoms b12 related, no large responses. Person 3 - mild body mb12 response at this dose, moderate CNS-mb12 response, no body adb12 response at this dose, huge CNS adb12-l-carnitine-fumarate response. Large healing startup response with both low potassium and low folate, no diagnoses, lots of symptoms but NOT folate deficiency symptoms intially and no mb12 body symptoms Person 4 - Huge body and CNS response to mb12. Huge startup response including low potassium and low folate. CFS, FMS and ???. Lots of symptoms Person 2 is typical of people taking these supplements where there has been no deferred healing or growth and they don't exhibit any of the possible diseases of the b12/folate deficiencies. What is very clear is that 50-100mcg of mb12/adb12 is sufficient to cause full fledged startup with induced low potassium and induced low folate. This is NOT caused by a large mb12 dose . There is not FORCED anything here. There is an attempt for the body to become "normal" again and mb12/metafolin are the most deficient items. 50mcg of mb12/adb12 is enough in sensitive people to start full blown healing. The hypothesis that Metafolin need is "created" by large mb12 doses is clearly ot supported at all. As I had previously said healing turns on suddenly by layers. It takes very little mb12 to start healing. No amount of hydroxycbl or cyanocbl starts much healing reliably. 50mcg of mb12/adb12 is vastly superior to any amount of hydroxcbl for most purposes. I would be most pleased to receive info of the type presented here on the ratios anybody else has established for themselves.