I have been trying to get this all ready for a grand, all at once posting and it just isn't working out. Instead I am going to post this in pieces for now with all sorts of parts revised. Overview - The problem biggest problem with the Active B12 protocol up to now has been the complications that are especially difficult all at once for those who like me had/have massive brain-fog. It took me 9 years to figure out and then it lacked all the specifics people wanted, and as individual answers were all individual, people got confused in trying to generalize. So I am going to do my best at trying to make it more clear, more definite and so on. Since it is a dynamic process I will be including a number of decision tree routine, a number of hold points by criteria for balancing and so on. I will be posting some of the components before I put down how they interact rather than trying to answer all the questions after posting the process. When I am directly coaching people through it I get much better results than somebody just trying it because of that dynamic process. So I will try to present that here. I have found that ORDER of supplements can be critical to success as are combinations. I will attempt to represent that as clearly as possible. I expect each and every post to need clarification and pribably revision as people ask questions and I try to explain it differently. A couple of years ago I indicated that there are the 4 basic b12 deficiency syndromes. Now I have also found 4 specific paradoxical folate deficiency or insufficiency syndromes and some other complications. Where I can I will distinguish how these differences affect the protocol. A lot of this we will find out together as additional areas get filled in on this matrix. Each time I learn a significant new piece of information, everything gets reconsidered and maybe revised, DISCLAIMER I am a self taught systems analyst and consultant. I am not credentialed, certified or licensed to do anything besides drive a car. I have been disabled by the disease processes being discussed here and affecting neurology in a multitude of ways for 10 years and impaired in a variety of ways and levels for 54 years before that. Everything I say is my opinion, synthesis, understanding or otherwise of my own creation except direct attributed quotes. Approximate paraphrases are also my interpretation of what I have read. All of this is at best my data analysis, understanding, synthesis and hypotheses and not to be construed as medical advice. I am not responsible for anything you do with any information provided in any way. Anything you do is your own responsibility and at your own risk. There are no published peer reviewed studies backing up my opinions or statements, except the incidental ones quoted or implicit in my synthesis or understanding, and then only in so far any reading of such papers may confer. Your interpretations, actions and variations of what I say are strictly at your own risk.